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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1973 1
1974 1
1975 2
1976 2
1977 3
1978 2
1979 3
1980 4
1981 3
1982 2
1983 1
1984 1
1985 6
1986 5
1987 6
1988 6
1989 5
1990 10
1991 5
1992 7
1993 14
1994 12
1995 10
1996 10
1997 6
1998 11
1999 17
2000 23
2001 31
2002 35
2003 32
2004 40
2005 51
2006 37
2007 53
2008 48
2009 48
2010 57
2011 64
2012 60
2013 46
2014 61
2015 69
2016 63
2017 68
2018 65
2019 66
2020 75
2021 78
2022 81
2023 82
2024 41

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1,426 results

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Page 1
Organocatalytic enantioselective reactions involving prochiral carbocationic intermediates.
Lei CW, Mu BS, Zhou F, Yu JS, Zhou Y, Zhou J. Lei CW, et al. Chem Commun (Camb). 2021 Sep 14;57(73):9178-9191. doi: 10.1039/d1cc03506a. Chem Commun (Camb). 2021. PMID: 34519317 Review.
The state-of-the-art research in this field is to overcome the intrinsic instability and high reactivity of the prochiral carbocationic intermediates to develop catalytic asymmetric reactions. ...With the rapid developments in modern asymmetric organocatalysis, a variety o …
The state-of-the-art research in this field is to overcome the intrinsic instability and high reactivity of the prochiral carbocation …
Transition-Metal Catalyzed Stereoselective Desymmetrization of Prochiral Cyclohexadienones.
Munakala A, Phanindrudu M, Chegondi R. Munakala A, et al. Chem Rec. 2021 Dec;21(12):3689-3726. doi: 10.1002/tcr.202100136. Epub 2021 Jun 19. Chem Rec. 2021. PMID: 34145713 Review.
The development of transition-metal catalyzed enantioselective and diastereoselective transformations has contributed many advances in the field of synthetic organic chemistry. Particularly, stereoselective desymmetrization of prochiral cyclohexadienones represents a power …
The development of transition-metal catalyzed enantioselective and diastereoselective transformations has contributed many advances in the f …
Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes.
Sandvoß A, Wiest JM. Sandvoß A, et al. Chemistry. 2021 Apr 1;27(19):5871-5879. doi: 10.1002/chem.202004923. Epub 2021 Feb 2. Chemistry. 2021. PMID: 33274788 Free PMC article. Review.
This review highlights recent examples that harness the inherent reactivity of prochiral oxetanes and offers an outlook on the immense possibilities for synthetic application....
This review highlights recent examples that harness the inherent reactivity of prochiral oxetanes and offers an outlook on the immens …
Diastereoselective palladium-catalyzed functionalization of prochiral C(sp(3))-H bonds of aliphatic and alicyclic compounds.
Babu SA, Aggarwal Y, Patel P, Tomar R. Babu SA, et al. Chem Commun (Camb). 2022 Feb 22;58(16):2612-2633. doi: 10.1039/d1cc05649b. Chem Commun (Camb). 2022. PMID: 35113087 Review.
We highlight the reported developments of the palladium-catalyzed C-H activation and functionalization of the inactive/unreactive prochiral C(sp(3))-H bonds of aliphatic and alicyclic compounds. There exist numerous classical methods for generating contiguous stereogenic c …
We highlight the reported developments of the palladium-catalyzed C-H activation and functionalization of the inactive/unreactive prochir …
Enantioselective Giese Additions of Prochiral alpha-Amino Radicals.
Lahdenperä ASK, Bacoş PD, Phipps RJ. Lahdenperä ASK, et al. J Am Chem Soc. 2022 Dec 14;144(49):22451-22457. doi: 10.1021/jacs.2c11367. Epub 2022 Dec 1. J Am Chem Soc. 2022. PMID: 36454604 Free PMC article.
Amines featuring an adjacent stereocenter are important building blocks, and recent years have seen remarkable growth in methods forming these via prochiral alpha-amino radical intermediates. However, very few can exert control over the newly formed stereocenter. ...
Amines featuring an adjacent stereocenter are important building blocks, and recent years have seen remarkable growth in methods forming the …
Catalytic Enantioselective Desymmetrization of Prochiral Triacylamines via Pseudopeptidic Guanidine-Guanidinium Catalysis.
Qu H, Liang XS, Wang WJ, Zhao XH, Deng YH, An XT, Chu WD, Zhang XZ, Fan CA. Qu H, et al. Org Lett. 2022 Sep 23;24(37):6851-6856. doi: 10.1021/acs.orglett.2c02785. Epub 2022 Sep 14. Org Lett. 2022. PMID: 36103354
Triacylamines with C(s) symmetry have been explored in asymmetric organocatalysis, leading to the development of a novel catalytic enantioselective desymmetrization of prochiral triacylamines by methanolysis under the catalysis of chiral pseudopeptidic guanidine-guanidiniu …
Triacylamines with C(s) symmetry have been explored in asymmetric organocatalysis, leading to the development of a novel catalytic enantiose …
Catalytic Enantioselective Alkylation of Prochiral Enolates.
Wright TB, Evans PA. Wright TB, et al. Chem Rev. 2021 Aug 11;121(15):9196-9242. doi: 10.1021/acs.chemrev.0c00564. Epub 2021 Jul 26. Chem Rev. 2021. PMID: 34309362
., chiral auxiliaries, chiral alkali metal amide bases, chiral electrophiles, etc.). In this way, the enantioselective alkylation of prochiral enolates greatly improves the step- and redox-economy of this process, in addition to enhancing the scope and selectivity of these …
., chiral auxiliaries, chiral alkali metal amide bases, chiral electrophiles, etc.). In this way, the enantioselective alkylation of proc …
Chiral phase-transfer catalysis in the asymmetric alpha-heterofunctionalization of prochiral nucleophiles.
Schörgenhumer J, Tiffner M, Waser M. Schörgenhumer J, et al. Beilstein J Org Chem. 2017 Aug 22;13:1753-1769. doi: 10.3762/bjoc.13.170. eCollection 2017. Beilstein J Org Chem. 2017. PMID: 28904619 Free PMC article. Review.
Besides asymmetric C-C bond forming reactions the use of chiral phase-transfer catalysts for enantioselective alpha-heterofunctionalization reactions of prochiral nucleophiles became one of the most important field of application of this catalytic principle. ...
Besides asymmetric C-C bond forming reactions the use of chiral phase-transfer catalysts for enantioselective alpha-heterofunctionalization …
Revisiting prochirality.
Ochs RS, Talele TT. Ochs RS, et al. Biochimie. 2020 Mar;170:65-72. doi: 10.1016/j.biochi.2019.12.009. Epub 2019 Dec 17. Biochimie. 2020. PMID: 31862235
We propose a new model for prochirality that satisfies all known examples: the prochiral plane. ...An example of a prochiral unnatural substrate for sphingosine kinase 2, fingolimod, has an sp(3) hybridized prochiral carbon and also contains a proch …
We propose a new model for prochirality that satisfies all known examples: the prochiral plane. ...An example of a prochira …
Copper-catalysed asymmetric reductive cross-coupling of prochiral alkenes.
Yoon WS, Jang WJ, Yoon W, Yun H, Yun J. Yoon WS, et al. Nat Commun. 2022 May 11;13(1):2570. doi: 10.1038/s41467-022-30286-8. Nat Commun. 2022. PMID: 35545634 Free PMC article.
Herein, we report an efficient strategy to reductively couple two prochiral conjugate alkenes using a copper-catalysed tandem protocol in the presence of diboron. ...
Herein, we report an efficient strategy to reductively couple two prochiral conjugate alkenes using a copper-catalysed tandem protoco …
1,426 results